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Autoantibodies

Autoantibodies
 
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ANA
Collagen vascular disease
% positive ANA
 
CREST (Limited systemic sclerosis)
85-90
Dermatomyositis (adult)
»70-80
Dermatomyositis (child)
»20
Discoid LE
»10
Drug induced subacute cutaneous LE
»75
Drug-induced SLE
>95
Generalized systemic sclerosis
»90-95
Neonatal LE
>95
Normal individuals
»5
Sjögren’s syndrome
»70-80
Subacute cutaneous LE (SCLE)
>70
Systemic lupus erythematosus (SLE)
>95
 
 
ANA patterns          Antibody producing pattern and related skin disorders
Centromeric
Anti-centromere: generalized systemic sclerosis (20%), CREST (50-70%)
Cytoplasmic
Anti-Ro/SS-A: SLE (40%), SCLE (75%), drug-induced SCLE (>80%), neonatal LE (>95%), Sjogren’s syndrome (50-80%)
Anti-tRNA synthetases (anti-Jo-1): dermatomyositis(<20%)
Anti-mitochondrial: primary biliary cirrhosis (>90%)
Nuclear; diffuse (homogenous smooth)
Anti-double strand DNA: specific for SLE (60%)
Anti-histone: drug induced SLE (>95%)
Nuclear; rim (peripheral)
Anti-nuclear pore, anti-lamin: SLE (rare)
anti-dsDNA
Nuclear; speckled (particulate)
Anti-Ro/SS-A: SLE (40%), SCLE (75%), drug induced SCLE (>80%), neonatal LE (>95%), Sjögren’s syndrome (50-80%)
La/SS-B: same as Ro/SS-A
Anti-U1RNP: SLE (35%), mixed connective tissue disease (>95%)
Anti-Scl 70 (DNA topoisomerase 1): generalized systemic sclerosis (33%), CREST (18%)
Anti-Sm: specific for SLE (25-40%)
Nucleolar
Anti-nucleolar (anti-RNA polymerase): generalized systemic sclerosis (40-50%), CREST (<20%)
 
Source: Daniel McCauliffe, MD

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