Therapy

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Therapy (unusual and regimes)

alpha methyldopa

Raynaud’s s.

aluminum chloride

Hailey-Hailey d.

aminocaproic acid

angioedema

amphotericin B

mucocutaneous leishmaniasis

anthralin

alopecia areata

antidepressants

chronic urticaria (doxepin), paroxysmal pruritus, pruritus vulvae

antimalarials

dermatomyositis, hydroa vacciniforme, inflammatory morphea, PMLE, reticular erythematous mucinosis, solar urticaria,

aspirin

atrophie blanche, Degos’ d., erythromelalgia, Kawasaki’s d., polyarteritis nodosa

azathioprine

dermatomyositis, erythroderma, immunobullous disease, LE, leukocytoclastic vasculitis, livedo reticularis, pemphigus, persistent light reaction, PRP, PSS, pyoderma gangrenosum

azelic acid

acne

benzodiazepines

causalgia

b-carotene

DLE, erythropoietic protoporphyria

bleomycin

genital warts, keratoacanthoma

calcium gluconate

periungual chemical burns

cantharidin

molluscum, verrucae

capsaicin

post-herpetic neuralgia, pruritus

carbachol

Chediak-Higashi s.

carmustine (BCNU)

lymphomatoid papulosis, mycosis fungoides

charcoal

erythrocytic porphyria, pruritus of renal dialysis

chlorambucil

mucinoses

chloripramine

trichotillomania

chloroquine

PCT, REM s.

cholestyramine

biliary pruritus, circumileostomy eczema, PCT, primary biliary cirrhosis

cimetidine

chronic mucocutaneous candidiasis, Kaposi’s sarcoma

clindamycin

Fox-Fordyce d., rosacea, vulvovaginal LP

clofazimine

DLE, pyoderma gangrenosum, Sweet’s s.

clonidine

hyperhidrosis

colchicine

amyloidosis, aphthae, Behçet’s disease, EBA, erythema nodosum, familial Mediterranean fever, idiopathic thrombocytopenic purpura, leukocytoclastic vasculitis, nodular vasculitis, palmoplantar pustular psoriasis, PG, pustular psoriasis, Sweet’s s.

cyclophosphamide

allergic granulomatosis, dermatomyositis, erythroderma, immunobullous disease, leukocytoclastic vasculitis, mucinoses, pemphigus, polyarteritis nodosa, PSS, Wegener’s granulomatosis

cyclosporin A

aphthous ulcers, atopic dermatitis, alopecia areata, Behçet’s disease, dermatomyositis, EBA, erosive LP, generalized granuloma annulare, GVHD, pemphigus, pompholyx, psoriasis, pustulosis palmaris et plantaris, pyoderma gangrenosum, Reiter’s s., scleroderma, urticaria/angioedema

cyproheptadine

acanthosis nigricans, acne, carcinoid s., cold urticaria

DMSO

lipoid proteinosis, primary amyloidosis, Raynaud’s ulceration

dacarbazine

KS, melanoma

danazol

acne, angioedema, idiopathic thrombocytopenic purpura, premenstrual exacerbation of SLE, urticaria

dapsone

acropustulosis of infancy, acne conglobata, acne fulminans, actinomycosis, alopecia mucinosa, alpha 1 antitrypsin deficiency panniculitis, benign mucosal pemphigoid, brown recluse spider bites, bullous LE, bullous pemphigoid (young patients), chronic bullous disease of childhood, cicatricial pemphigoid, dermatitis herpetiformis, EED, GA, granuloma faciale, Hailey-Hailey d., Henoch-Schönlein purpura, LP/LE overlap, leishmaniasis, leprosy, leukocytoclastic vasculitis, linear IgA d., lymphomatoid papulosis, palmoplantar pustular psoriasis, pemphigus foliaceus, pemphigus vulgaris, pyoderma gangrenosum, relapsing polychondritis, SCLE, urticarial vasculitis

dexamethasone

hirsutism

dibutyl ester

alopecia areata

dilantin

DEB, JEB, glucagonoma, morphea

diltiazem

hyperhidrosis

dinitrochlorobenzene

alopecia areata

diphencyprone

alopecia areata

disodium cromoglycate

mastocytosis (relief of GI, skin & CNS symptoms)

disulfiram

nickel sensitivity

DMSO

hereditary localized pruritus

doxycycline

bullous pemphigoid

epinephrine

angioedema, mastocytosis

estrogens

hereditary hemorrhagic telangiectasia, rosacea

etoposide

Langerhan’s cell histiocytosis

etretinate

keratoacanthoma, LP, PRP, psoriasis, pustular psoriasis, pustulosis palmaris et plantaris

evening primrose oil

atopic dermatitis

finasteride

androgenetic alopecia, hirsutism

fluoxetine

skin picking

flutamide

hirsutism

5-fluorouracil

actinic keratoses, basal cell epithelioma (superficial), condyloma, erythroplasia of Queyrat, KA (IL and topically), Paget’s d., verrucae

fotemustine

melanoma

gentamicin

protothecosis

gold

DLE (Auranofin), pemphigus, psoriatic arthritis

grenz ray

lichen simplex chronicus

guanethidine

Raynaud’s d.

hydroxychloroquine

DLE, PCT, REM s., subacute LE

IFN-a

episodic angioedema, hypereosinophilic s.

IFN-g

atopic dermatitis

indomethacin

Reiter’s s.

interferon (a & g)

basal cell epithelioma, BCC, SCC, warts (genital), vulvodynia

isotretinoin

Darier’s disease, DLE, ichthyoses, mucinoses, PRP, psoriasis (pustular, erythrodermic)

itraconazole

protothecosis

ketanserin

Raynaud’s phenomenon

ketotifen

physical urticaria

KI

Sweet’s s., erythema nodosum, subacute nodular migratory panniculitis, granuloma annulare, nodular vasculitis, blastomycosis, zygomycosis

levamisole

LP, SLE

masoprocol

actinic keratoses

melphalan

papular mucinoses, primary systemic amyloidosis

mercury

yellow oxide of mercury for eyelash pediculosus

metronidazole

acute necrotizing gingivitis, anaerobic infection of leg ulcers, rosacea

methotrexate

dermatomyositis, erythroderma, Hailey-Hailey d., immunobullous disease, keloids, keratoacanthoma, lymphomatoid papulosis, multicentric histiocytosis, Norwegian scabies (crusted), PLEVA, PRP, psoriasis

minoxidil

alopecia areata

niacinamide

bullous pemphigoid, granuloma annulare, Hartnup d.

nifedipine

Raynaud’s s.

nitrogen mustard

CTCL

OCPs

acne, hirsutism

papaverine

atopic dermatitis

pentoxyfylline

atrophie blanche, CNCH, leukocytoclastic vasculitis, livedo reticularis, PLEVA, Raynaud’s s.

phlebotomy

PCT

photopheresis

CTCL, cutaneous sclerosis, GVH d.

pimozide

acarophobia, acne excor¾e, dermatitis artefacta, delusion of parasitosis, monosynaptic hypochondriasis, onychotillomania, orodynia, total lipodystrophy

plasmapheresis

mucinoses, pemphigus

podofilox

condyloma

prazequantel

cysticercosis, schistosomiasis

prazosin

Raynaud’s phenomenon

prolixin

acarophobia

propylene glycol

2:1 mixture with water for softening calluses/corns

psoralen + UVA PUVA

allergic contact dermatitis, alopecia areata, alopecia mucinosa, atopic dermatitis, CTCL, erythropoietic protoporphyria, granuloma annulare, Grover’s d., GVH d., hydroa vacciniforme, LP, mastocytosis, morphea, persistent light reactor, pityriasis lichenoides chronica, lymphomatoid papulosis, parapsoriasis, pityriasis lichenoides, PLEVA, PMLE, polycythemia vera, pompholyx, PRP, psoriasis, pustulosis palmaris et plantaris, scleroderma, solar urticaria, urticaria pigmentosis, vitiligo

rePUVA

combination systemic retinoids plus PUVA for psoriasis

retinoids

aphthae, BCC, Darier’s d., Grover’s d., hidradenitis suppurativa, KA, keratodermas, LE, psoriasis, rosacea, SC, XP

spironolactone

acne, hirsutism

squaric acid

alopecia areata

sulfur

scabies (pregnant women & infants <2 months old)

stanozolol

atrophie blanche, cryofibrinogen leg ulcers, cutaneous polyarteritis nodosa, NLD

thalidomide

actinic prurigo, aphthous ulcers (AIDS), chronic GVH, erythema nodosum leprosum, LE, PMLE, uremic pruritus

trimethoprim-sulfamethoxasole

chronic granulomatous d., nocardiosis

testosterone

lichen sclerosis

tetracycline

Vibrio infections, protothecosis

thalidomide

aphthae, Behçet’s d., erythema nodosum leprosum, lupus profundus, prurigo nodularis, systemic nodular panniculitis (Weber-Christian)

thiabendazole

seabather’s eruption

UVA/UVB

atopic dermatitis, pruritus

vinblastine

Kaposi’s sarcoma

vitamin A

acneiform eruptions, acne, corns, Darier’s d., Grover’s d.

vitamin C

alkaptonuria, Chediak-Higashi s., Ehlers-Danlos type VI, miliaria

vitamin D

psoriasis, parapsoriasis

zinc sulfate

alopecia areata

Disease Therapy

a-1 antitrypsin deficiency panniculitis

dapsone

acanthosis nigricans

cyproheptadine

acarophobia

pimozide, prolixin

acne

azelic acid, cyproterone, danazol, spironolactone, vitamin A

acne conglobata

dapsone

acne excoree

pimozide

acne fulminans

dapsone

acneiform eruptions

vitamin A

acropustulosis of infancy

dapsone

actinomycosis

dapsone

acute necrotizing gingivitis

metronidazole

alkaptonuria

vitamin C

allergic granulomatosis

cyclophosphamide

alopecia areata

anthralin, cyclosporine A, dibutyl ester, dinitrochlorobenzene, diphencyprone, minoxidil, squaric acid, zinc sulfate

alopecia mucinosa

dapsone, psoralens

amyloidosis, primary

DMSO

angioedema

aminocaproic acid, danazol

aphthae

colchicine, thalidomide

atopic dermatitis

evening primrose oil, papaverine, psoralens

atopy

cyclosporine A

atrophie blanche

pentoxyfylline, stanozolol, aspirin

Behçet’s d.

thalidomide

benign mucosal pemphigoid

dapsone

biliary pruritus

cholestyramine

blastomycosis

KI

brown recluse spider bite

dapsone

bullous LE

dapsone

bullous pemphigoid

dapsone, doxycycline, niacinamide

causalgia

benzodiazepines

Chediak-Higashi s.

carbachol, vitamin C

chronic bullous disease of childhood

dapsone

chronic granulomatous d.

trimethoprim-sulfamethoxasole

chronic mucocutaneous candidiasis

cimetidine

CNCH

pentoxyfylline

cold urticaria

cyproheptadine

corns

vitamin A

corns/calluses

propylene glycol

cryofibrinogen leg ulcers

stanozolol

cutaneous polyarteritis nodosa

stanozolol

cysticercosis

prazequantel

Darier’s d.

dermabrasion, laser, oral retinoids, oral vitamin A

DEB

dilantin

Dego’s d.

aspirin

dermatitis artefacta

pimozide

dermatitis herpetiformis

dapsone

dermatomyositis

antimalarials, azathioprine, cyclophosphamide, methotrexate

DLE

beta-carotene, clofazimine, hydroxychloroquine, isotretinoin, gold

eczema, circumileostomy

cholestyramine

EED

dapsone

Ehlers-Danlos type VI

vitamin C

entomophthoromycosis

KI

erythema nodosum

colchicine, KI

erythema nodosum leprosum

thalidomide

erythrocytic porphyria

charcoal

erythroderma

azathioprine, cyclophosphamide, methotrexate

erythromelalgia

aspirin

familial Mediterranean fever

colchicine

glucagonoma

dilantin

Goeckerman regime

treatment of psoriasis; UV plus crude coal tar

granuloma annulare

dapsone, KI, niacinamide

granuloma annulare, generalized

cyclosporine A

granuloma faciale

dapsone

Grover’s d.

PUVA, retinoids (oral), steroids, vitamin A

Hailey-Hailey d.

aluminum chloride hexahydrate 6.25%, dapsone, vitamin E, methotrexate, cyclosporin (topical)

harlequin fetus

oral retinoids

Hartnup d.

niacinamide

Henoch-Schönlein purpura

dapsone

hereditary hemorrhagic telangiectasia

estrogens

hirsutism

dexamethasone, finasteride, flutamide, OCPs, spironolactone

hydroa vacciniforme

antimalarials

hyperhidrosis

clonidine, diltiazem

idiopathic thrombocytopenic purpura

colchicine, danazol

inflammatory morphea

antimalarials

Ingram treatment

anthralin paste, UV & wraps; psoriasis treatment

JEB

dilantin

Kaposi’s sarcoma

cimetidine

Kawasaki’s d.

aspirin

keloids

methotrexate

keratoacanthoma

bleomycin, etretinate, 5-fluorouracil, methotrexate

keratoderma

biotin, salicylic acid, retinoids (oral), vitaminD3 analog,

LE

azathioprine

leg ulcers, anaerobic infection 

metronidazole

leishmaniasis

dapsone

leukocytoclastic vasculitis

colchicine, pentoxyfylline

lichen planus

levamisole

lichen planus, lupus erythematosus overlap

dapsone

lichen sclerosis

steroids

lichen simplex chronicus

grenz ray

linear IgA bullous dermatosis

dapsone

livedo reticularis

azathioprine

lupus profundus

thalidomide

lymphomatoid papulosis

carmustine (BCNU), dapsone, methotrexate

mastocytosis

psoralens

miliaria

vitamin C

monosynaptic hypochondriasis

pimozide

morphea

dilantin

mucocutaneous leishmaniasis

amphotericin B

multicentric histiocytosis

methotrexate

mycosis fungoides

carmustine (BCNU)

necrobiosis lipoidica diabeticorum

stanozolol

nickel sensitivity

disulfiram

nocardiosis

trimethoprim-sulfamethoxasole

nodular vasculitis

colchicine

Norwegian scabies

methotrexate

onychotillomania

pimozide

orodynia

pimozide

palmoplantar pustular psoriasis

colchicine, dapsone

panniculitis, subacute nodular migratory

KI

parapsoriasis

psoralens, vitamin D

paroxysmal pruritus

amitryptiline

PCT

phlebotomy

pediculosis, eyelash

mercury, petrolatum

pemphigus foliaceus

dapsone

pemphigus vulgaris

dapsone

periungual chemical burns

calcium gluconate

persistent light reactor

azathioprine, psoralens

pityriasis lichenoides chronica

psoralens

PLEVA

methotrexate, pentoxyfylline, psoralens

PMLE

antimalarials, psoralens

polyarteritis nodosa

aspirin, cyclophosphamide

polycythemia vera

psoralens

pompholyx

psoralens (PUVA)

premenstrual exacerbation of SLE

danazol

primary biliary cirrhosis

cholestyramine

protothecosis

gentamicin, itraconazole, tetracycline

PRP

azathioprine, etretinate, methotrexate

prurigo nodularis

thalidomide

pruritus

antihistamines, capsaicin, diphenhydramine, doxepin cream, pramoxine HCl

pruritus of renal dialysis

charcoal

pruritus vulvae

amitryptiline

pruritus, hereditary localized

DMSO

psoriasis

cyclosporine A, vitamin D

PSS

azathioprine, cyclophosphamide

pustular psoriasis

colchicine, etretinate

pyoderma gangrenosum

azathioprine, clofazimine, dapsone, mycophenolate mofetil

Raynaud’s s.

alpha methyldopa, nifedipine

Raynaud’s ulceration

DMSO

relapsing polychondritis

dapsone

reticular erythematous mucinosis

antimalarials

rosacea

azelaic acid, clonidine, estrogens, metronidazole, retinoids, spironolactone

schistosomiasis

prazequantel

SCLE

dapsone

seabather’s eruption

thiobendazole

skin picking

fluoxetine

SLE

levamisole

solar urticaria

antimalarials, psoralens

Sweet’s s

KI, colchicine, clofazimine

systemic nodular panniculitis (Webber-Christian)

thalidomide

total lipodystrophy

pimozide

urticaria pigmentosis

psoralens

urticaria, chronic

Doxepin

urticaria, physical

ketotifen

urticarial vasculitis

dapsone

vasculitis, nodular

KI

Vibrio infections

tetracycline

Wegener’s granulomatosis

cyclophosphamide

zygomycosis

KI

  

Herbal Therapy

acne

burdock root, tea tree oil, yellow dock

bruising

arnica, capsaicin, comfrey

burns

aloe vera, calendula

eczema

aloe vera, burdock, chamomile, evening primrose oil, witch hazel

herpes

lemon balm

onychomycosis

tea tree oil

pruritis

capsaicin, chamomile, chickweed

psoriasis

aloe vera, burdock root, capsaicin, milk thistle, red clover,  yellow dock

shingle pain

capsaicin

tinea pedis

garlic, tea tree oil

ulcers, wounds

aloe vera, arnica, calendula, comfrey, echinacea, goldenseal, tea tree oil

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